Advancing Diabetes Research: A Novel Islet Isolation Method from Living Donors.

Isolated pancreatic islets exhibited functional responses to glucose and arginine stimulation mirroring donors’ metabolic profiles, with insulin secretion significantly decreasing in diabetic islets compared to non-diabetic islets; conversely, proinsulin secretion showed an increasing trend from non-diabetic to diabetic islets.

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Preliminary data on a small sample set (ND = 3; DM = 3) show a clear trend of increased baseline (3 mM glucose) insulin secretion in non-diabetics compared to DM and a response to high glucose + arginine, which is not observed in diabetic subjects ( Figure S3 ).

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