Triple Blockade of Oncogenic RAS Signaling Using KRAS and MEK Inhibitors in Combination with Irradiation in Pancreatic Cancer.

There was a numerical reduction in colony counts upon combined KRAS inhibition with BI-3406 plus Binimetinib treatment in combination with irradiation, but this reduction did not reach statistical significance when applied in KRAS G12C mutant MiaPaCa cells ( Figure 5 a,b).

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