Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications.

Installing H3K4me3 to the OFF reporter caused a highly significant secondary depletion of the Polycomb mark H3K27me3 (Fig. 3g ), which is the reciprocal response to removing H3K4me3 (Extended Data Fig. 5c,d ).

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Upon DOX induction of Prdm9-CD scFV to restore H3K4me3, all targeted genes showed a trend of reactivation, with five out of seven reaching significant transcriptional rescue, including Setmar , Ttll4 and Ddx4 (Fig. 3c and Extended Data Fig. 6a,b ).

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