Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart.

J Am Heart Assoc · 2024 · PMC11179765 · PMID 38533937

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0.0013

closest p · 0.0× alpha

0.0680

boldest claim

The sentences

failed to reach significanceP =0.0013actually significant

While the increase in the AMPKβ1 isoform alone failed to reach significance, we observed an increase in its activated form, p‐AMPKβ1 (Ser108) (64.5%; P =0.0013; Figure 3A ) in cKO animals.

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failed to reach statistical significanceP =0.068so close (0.05 < p ≤ 0.1)

18 , 34 , 35 Respirometry with pyruvate and malate as substrates exhibited a trend toward greater ADP‐dependent (state 3) respiration in cKO relative to control hearts, though this difference failed to reach statistical significance ( P =0.068; Figure 4A ).

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