Based on this observation, detailed GO-enriched biological processes including broader aspects of protein histone modifications were plotted as a heatmap, showing a clear trend that histone demethylation and deacetylation processes were upregulated under the Prediff condition while the histone methylation and acetylation processes were downregulated ( Fig. 3 C).
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Nanofiber-microwell cell culture system for spatially patterned differentiation of pluripotent stem cells in 3D.
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