showed a trendp = 0.182
Vinflunine showed a trend towards improved OS; median OS in vinflunine vs BSC group was 16.7 months vs 13.2 months respectively (HR-0.736; 95% CI, 0.44–1.24, p = 0.182); objective responses were achieved in 21% patients in vinflunine group vs 7% in BSC group respectively and vinflunine had an acceptable safety profile.