Iron overload and chelation modulates bisretinoid levels in the retina.

In albino C57BL/6J c2j mice, a 1.4-fold increase in A2PE and a 3.8-fold increase in atRALdi were observed 2 days after the intravitreal injection of FAC ( Figure 1C ) although these differences, relative to saline injection, did not reach statistical significance ( p > 0.05, two-way ANOVA, and Sidak’s multiple comparison test) ( Figure 1C ).

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