Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation.

The methylation of H3R2A arrays was reduced (49%) though did not reach statistical significance ( p = 0.18), suggesting that the complete loss of H3K27me3 on H2R2 mutant histones in the cellular context as determined by immunoblot is mediated by factors in addition to direct effects on the core PRC2 complex.

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This was markedly different from the magnitude and number of highly significant differences in H3K27me3 signal at H3K27me3 differential peaks in the same samples (Supplementary Fig.

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