IL-21 conditions antigen-presenting human γδ T-cells to promote IL-10 expression in naïve and memory CD4⁺ T-cells.

In contrast, neutralising antibodies against CD70, 4-1BBL, OX40L, or ICOSL had no such effect on the expression of IL-10; inhibition of CD40 signalling exerted a minor influence that failed to reach statistical significance ( Fig. 3A ).

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