Changes of brain parenchyma free water fraction reflect tissue damage and impaired processing speed in multiple sclerosis.

FWF spatial variance in NAWM decreased with SDMT score in 16 ROIs in MS patients, including the genu and body of corpus callosum, corticospinal tract (cst) right and left (approaching significance for the first one), the sagittal stratum right and left, the superior cerebellar peduncle right, the alic‐R, the superior longitudinal fasciculus (slf) right, approaching significance for slf‐left (see Table S2 and Figure 6 ). 4 DISCUSSION This study quantified cerebral FWF in clinically stable RRMS and investigated its relationship with lesion burden and information processing speed.

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