Diagnostic Utility of Integration of Dynamic Contrast-Enhanced and Dynamic Susceptibility Contrast MR Perfusion Employing Split Bolus Technique in Differentiating High-Grade Glioma.

The k-trans value, although higher in grade III than in grade IV gliomas, did not reach statistical significance ( p = 0.108).

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rious confounding factors (type of pharmacokinetic model, contrast agent, and T10, among others) while comparing results among the studies. 31 32 33 The literature search reveals varying degrees of correlation between the rCBV and k-trans values with glioma grade. 28 Santarosa et al found a highly significant positive correlation of tumor grade with k-trans, Vp, and rCBV, with the highest correlation noted for Vp. 14 Although differentiating low-grade diffuse gliomas from HGGs is relatively easy with MR perfusion, studies show substantial overlap in differentiating WHO grade III from grade IV diffuse

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