AT8 phosphorylation with immunoprecipitated tau P301L was decreased by more than 50% compared to tau WT , although this failed to reach statistical significance (Ratio-paired t -test, p = 0.089).
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Tau<sup>P301L</sup> disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability.
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0.0890
0.0890