Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1.

In the case of the N309K mutation, the M-833 EC 50 values were reduced by similar amounts to the WT parasites in the presence of 2.5 mM GlcN (2.5-fold reduction for SLI-N309K, 5.2-fold reduction for CR-N309K), although this did not reach statistical significance.

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