Regulation of vascular endothelial integrity by mesenchymal stem cell extracellular vesicles after hemorrhagic shock and trauma.

J Transl Med · 2024 · PMC11191310 · PMID 38907252

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Compared to sham mice, LR-treated mice had significantly higher levels of IL-10, MMP-8, MMP-9, TNFRSF1b, and VEGF, MSC-treated mice had higher levels of TNFRSF1b and showed a trend toward higher levels of CXCL12 (p = 0.06), and EV-treated mice had higher levels of IFN-y, IL-1B, IL-6, IL-10, MMP-8, MMP-9, TNFa, TNFRSF1b, and VEGF and showed a trend toward higher levels of CXCL10 (p = 0.06) and CXCL12 (p = 0.06).

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