showed a trendp = 0.08
In the experimental treatment versus bevacizumab subgroup, all studies failed to show a significant improvement of PFS, although HDAC‐inhibition with vorinostat and bevacizumab 37 showed a trend towards prolonged PFS (RR 0.63, 95% CI 0.37–1.06; p = 0.08; n = 85).