ADA/CD26 axis increases intra-tumor PD-1<sup>+</sup>CD28<sup>+</sup>CD8<sup>+</sup> T-cell fitness and affects NSCLC prognosis and response to ICB.

When we compared IFN-γ and TNF-α production between CD28 − and CD28 + in cells co-expressing ADA and CD26, we detected apparent higher cytokine levels in PD-1 + CD28 + T cells, although the differences did not reach statistical significance.

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