showed a trendP = .17
Moreover, the haplotype analysis demonstrated that the risk allele of rs111321460 was consistently present in the same haplotype as the risk allele of rs112735431 and that the low-frequency haplotype containing the risk variant of rs112735431 and the reference allele of rs111321460 still showed a trend of association (OR, 1.40; 95% CI, 0.83-2.23; P = .17) (eTable 4 in Supplement 1 ).