Changes of cardiac function: cardiac adaptation in patients with hypothyroidism assessed by cardiac magnetic resonance-a meta-analysis.

Using fixed-effects model, the results showed that the patients with hypothyroidism had a marginally significant reduction in CI compared with healthy controls (WMD=-0.53, 95%CI[-0.65, -0.41], P <0.00001), and heterogeneity analysis showed large heterogeneity (Tau2=0.21, Chi2=44.02, P < 0.00001, I 2 = 93%).

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It is consistent with our results, as most studies showed a trend towards a reduction in LVEF ( 19 , 20 ), CI ( 20 , 21 ), and SV ( 20 , 21 ) reduction in patients with hypothyroidism was found in most studies, although most studies did not show a significant difference.

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