Chronic Liver Enzyme Elevation and Use of Contemporary ARVs Among People With HIV.

We confirmed previous studies’ findings that use of EFV, RPV, and TDF was associated with an increased risk of cLEE [ 22 , 24 , 28 , 29 , 30 ]; although EFV and RPV did not reach statistical significance after adjusting for region of care, the point estimate remained in the same direction, just losing statistical significance.

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We did find an elevated risk of cLEE with use of NNRTIs (driven by EFV, RPV) and TDF, a decreased risk of cLEE with DRV/b use, and a nonsignificant trend toward decreased risk of cLEE with TAF.

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