Kaplan–Meier estimates for the three treatment arms did not differ significantly but showed a trend for improved median survival for animals receiving QTP or QTP + atorvastatin during radiation treatment ( Fig. 4E ) in line with QTP preventing radiation-induced phenotype conversion of non-stem GBM cells into GSCs and atorvastatin affecting the mevalonate pathway in surviving cells.
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Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1.
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