Orexin receptor 2 agonist activates diaphragm and genioglossus muscle through stimulating inspiratory neurons in the pre-Bötzinger complex, and phrenic and hypoglossal motoneurons in rodents.

PLoS One · 2024 · PMC11198781 · PMID 38917189

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did not reach statistical significanceno p-value reported

Although OX-201 showed similar trends in both inspiratory and expiratory time, the effects of OX-201 on expiratory time did not reach statistical significance at up to 3 mg/kg in this study ( Fig 7F and 7G ).

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