SNM1A is crucial for efficient repair of complex DNA breaks in human cells.

Interestingly, when we evaluated the spatial relationship of these Zeocin-induced EGFP-SNM1A foci relative to 53BP1 and γH2AX foci, there was a clear trend that SNM1A PIP cells exhibited a reduced average number of foci proximal or overlapping with both DSBs markers (Supplementary Fig. 10 ), implying a role for the SNM1A PIP box in the localisation of SNM1A to complex breaks.

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