Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling.

In addition, 5 mM leucine plus 20 mM glucose showed a trend of potentiated insulin secretion in human islets but not in SC-islets ( Figures 4B,C ).

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In addition, once a mitochondrial pyruvate carrier (MPC) blocker, UK-5099, was added to the incubation buffer, the glucose oxidation was significantly inhibited in SC-islets, whereas only a decreasing trend observed in human islets ( Figure 5F ), indicating that the 14 CO 2 production was highly dependent on following mitochondrial metabolism after glycolysis in SC-islets and human islets.

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