While a slight reduction in CD206 expression was observed in WT mice treated with 50 mg/kg CDDO-Me, this trend did not reach statistical significance, again demonstrating the dose-dependent effects of CDDO-Me ( Figure 2 B).
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The Triterpenoid CDDO-Methyl Ester Reduces Tumor Burden, Reprograms the Immune Microenvironment, and Protects from Chemotherapy-Induced Toxicity in a Preclinical Mouse Model of Established Lung Cancer.
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