Loss of c-Kit in Endothelial Cells Protects against Hindlimb Ischemia.

As shown in Figure 4 , while the control group (WT VE-Cadherin CreERT2) displayed baseline collateral remodeling, mice with the loss of endothelial c-Kit (c-Kit VE-Cadherin CreERT2) showed a trend of improved arteriogenesis and mice with the loss of endothelial SCF (SCF VE-Cadherin CreERT2) showed significant arteriogenesis. 4.

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In summary, this study is highly significant because it is the first to show the deleterious effect of endothelial c-Kit signaling on arteriogenesis after hindlimb ischemia, which is potentially associated with an impaired endothelial barrier.

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