The Immune Checkpoint BTLA in Oral Cancer: Expression Analysis and Its Correlation to Other Immune Modulators.

PD-L2 mRNA expression was statistically marginally significant and moderately positively correlated with BTLA protein expression (Spearman’s ρ = −0.24, p = 0.045).

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The statistic evaluation of immunohistochemical data revealed that the protein is substantially overexpressed in the epithelial part of the tumor group (mean LI BTLA_Epithelium OSCC = 0.31, mean LI BTLA_Epithelium NOM = 0.11, FC = 2.82), but this parameter did not reach statistical significance ( p = 0.184) ( Figure 4 A, Table 4 ).

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In tissue, there was a highly significant overexpression of CD96 in OSCC patients compared to the control group [ 11 ].

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