Transformation of ABT-199 Nanocrystal Suspensions into a Redispersible Drug Product-Impact of Vacuum Drum Drying, Spray Drying and Tableting on Re-Nanodispersibility.

But the data revealed a clear trend towards decreasing nano proportions with increasing compaction pressure independent of the drying process.

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Moreover, a slight trend towards higher d50 values was observed under most conditions, correlating with increasing drug load and, thus, correlating with decreasing drying protectant proportion.

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