Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2-V617F-positive myeloproliferative neoplasms.

Spleen weight was reduced by pegIFN-α in recipients of VF BM but showed a trend toward higher values in double-mutant VF;Dm Δ/Δ mice than vehicle controls ( Figure 2 D).

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