Type I conventional dendritic cells and CD8<sup>+</sup> T cells predict favorable clinical outcome of head and neck squamous cell carcinoma patients.

1/2) we observed that an ICIS of 1 to 2, reflecting a high infiltration of cDC1 and/or CD8 + T cells, was significantly associated with a higher LRC and highly significant in predicting a high LDMC ( Figure 10B ).

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Furthermore, a higher ICIS showed a strong trend for the prediction of prolonged OS ( Figure 10B ). 4 Discussion The significant influence of the immune landscape on tumor development, progression, as well as on therapeutic outcome, has been described for many solid cancers, including HNSCC.

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