Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA.

DCA siRNA htt and linker variants of PC-DCA siRNA htt also reduced htt mRNA expression compared to siRNA ntc but did not reach statistical significance for some variants ( Figure 2 C), indicating perhaps that the in vivo potency of siRNA htt is lower than that of siRNA cd47 and may be helpful in differentiating between the linker variants.

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