Therapeutic Modulation of Arginase with nor-NOHA Alters Immune Responses in Experimental Mouse Models of Pulmonary Tuberculosis including in the Setting of Human Immunodeficiency Virus (HIV) Co-Infection.

Moderate Effects of nor-NOHA in Balb/cJ Mice Infected with Mtb Balb/cJ mice infected with Mtb (200 CFU, i.n.) and treated with nor-NOHA (0.04 mg/g i.p.) daily for 8 weeks ( Figure 3 A) showed a trend ( p = 0.077) towards a decrease in bacterial burden in the lungs ( Figure 3 B).

also in 53,322 other papers

An increase in IL-1β+ cells was observed following treatment with nor-NOHA, an effect that was highly significant in cells infected with Mtb.

also in 132,142 other papers