Association of ESR1 Germline Variants with TP53 Somatic Variants in Breast Tumors in a Genome-wide Study.

AFA-specific analyses for these variants showed a trend for association with rs9479090 and having any TP53 mutation (OR = 1.33, P value 0.02; Table 3 ).

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Variants showing a nonsignificant trend for association in more than one dataset included rs10931697 for TP53 GOF in the EUR validation, AFR validation, and MyBrCa studies ( P values 0.008, 0.02, and 0.09, respectively), and rs6709393 ( P values 0.003 and 0.16) in the MyBrCa and B-CAUSE studies.

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