Upon subsequent qRT-PCR analysis, alterations in WNT target mRNAs Axin2 , Apcdd1 and Cldn5 between Gpr124 +/− and Gpr124 ΔC /− endothelium did not reach statistical significance, in contrast to more severe reductions in Gpr124 −/− ( Fig.
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GPR124 regulates murine brain embryonic angiogenesis and BBB formation by an intracellular domain-independent mechanism.
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