A druggable cascade links methionine metabolism to epigenomic reprogramming in squamous cell carcinoma.

Proc Natl Acad Sci U S A · 2024 · PMC11214090 · PMID 38900797

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a clear trendno p-value reported

A clear trend was also observed in ESCC patients, albeit without reaching statistical significance ( SI Appendix , Fig.

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highly significantno p-value reported

Therefore, both clinically and translationally, investigation of methionine metabolism is highly significant as it may identify cancer-specific metabolic vulnerabilities that can be readily exploited via diet intervention.

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