Sodium-glucose cotransporter 2 inhibitors induce anti-inflammatory and anti-ferroptotic shift in epicardial adipose tissue of subjects with severe heart failure.

To complement the results of gene expression analysis, serum levels of pro-inflammatory factors including TNFα, IL6 and INFγ were measured as well, showing an all-over trend to reduced values in the SGLT-2i+ group, although the difference did not reach statistical significance (Table 4 ).

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