ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase.

Coexpression was highly significant with CD44 , a marker of resistance to gemcitabine ( 26 ) ( Fig. 1 F ) and RRM1 ( Fig. 1 G ), which encodes the large subunit of ribonucleotide reductase, a target of gemcitabine activity.

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Next, to understand the impacts of cancer treatment, we investigated and found the chemotherapy regimen for patients with PAAD included gemcitabine, 5-fluorouracyl and oxiplatin; however, the percentage of patients receiving gemcitabine increased from the g_low to the g_medium to the g_high groups, although differences did not reach statistical significance ( Fig. 1 D ).

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