Integrative analysis of blood transcriptome profiles in small-cell lung cancer patients for identification of novel chemotherapy resistance-related biomarkers.

Although group differences in the expression levels of transcription factors did not reach statistical significance, possibly due to the small sample size, the primary resistance patients exhibited low NEUROD1 and ASCL1 expression before treatment, while the acquired resistance patients exhibited low NEUROD1 expression and high ASCL1 expression before treatment, with contrasting expression patterns after treatment.

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However, compared to the AR_pre group, the PR_pre group exhibited an increasing trend in class-switched memory B cells and CD4+ T cells among immune cell types, as well as a decreasing trend in pro B cells ( Figure 2E ).

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The immune cell scores estimated using xCell showed no significant differences among immune cells, including CD4+ T memory cells, natural killer (NK) T cells, and regulatory T cells, but exhibited a decreasing trend in variation ( Supplementary Figure S2–I ).

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