IFNγ-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease.

Additionally, we evaluated MASLD Activity Score (MAS), originally validated as a scoring system for human MASH 68 , 69 , and found a strong trend for less lobular inflammation and ballooning but similar steatosis in Lyz-IFNγR2 −/− mice compared to WT mice after the GAN diet, resulting in a modestly lower overall MAS in Lyz-IFNγR2 −/− mice (Fig. 5E ).

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