The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is severely constrained by random peptide mixtures.

There is however a strong trend for the occurrence of SNPs in phoQ to increase the lag time of the strains (X 2 1,50 = 3.63; p = 0.057; S13 Fig ), suggesting a fitness cost to the inactivation of the phoQ gene product. 5.

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