CETP and SGLT2 inhibitor combination therapy increases glycemic control: a 2x2 factorial Mendelian randomization analysis.

We perform the same analysis with dichotomous and continuous scores as detailed above to validate our CETP genetic score, finding that our SGLT2 score is associated with decreased glycated hemoglobin (dichotomized: p=0.0000426; continuous: p=0.000044), but increased systolic blood pressure (dichotomized: p=0.0116; continuous: p=0.00149) with increased BMI trending towards significance (dichotomized: p=0.172; continuous: p=0.0708) ( Figures 1C, D ; Supplementary Table 5 ).

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