Mendelian randomization analyses clarify the effects of height on cardiovascular diseases.

When we modeled FEV1 and FVC exclusively with height, the effect of height on CAD risk did not appear to be reduced by lung function (OR = 1.13, 95% CI = 1.10–1.16, p = 3.2 x 10 −17 , Fig 3E ), although the effects for both lung function measures were nominally significant at best (p FEV1 = 0.026 and p FVC = 0.052) Fourth, we created a restricted set of height genetic instruments that excluded variants nominally associated with FEV1 or FVC [ 24 ] (p < 0.05) to more directly compare between results from the published work suggesting lung function’s effect on height [ 5 ], and only retained variants present in lung function, height, and CAD GWAS.

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