Increased secretion of adipocyte-derived extracellular vesicles is associated with adipose tissue inflammation and the mobilization of excess lipid in human obesity.

5 b and d), and phosphorylated hormone sensitive lipase (HSL) protein levels showed a decreasing trend (Fig. 5 c).

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Interestingly, our results tentatively suggest an increasing trend of glycerol levels in culture medium, despite the decreased PNPLA2 and LIPA mRNA expression, as well as phospho-HSL protein levels.

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There were also indications of different FA proportions between the EV types, although most of these changes did not reach statistical significance: PLA proportion was significantly higher in EVs from the mature cells compared to pre-SGBS EVs, and α-linolenic acid (ALA, 18:3n-3), 19:0, and 20:1n-9 tended to have higher average values in EVs from the mature cells compared to EVs from the pre-SGBS cells, while γ -linolenic acid (GLA, 18:3n-6) proportions seemed to be higher in pre-SGBS EVs (Fig. 1 j).

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