Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice.

A clear trend emerged for reduced susceptibility to fatigue in NNMTi-treated mice relative to matched controls (Supplemental Fig. 1 ; Supplemental Table 1 ; main effect of NNMTi treatment on repetitions above 70% in the fatigue test, P = 0.098).

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