A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia.

While PT rats showed increased circulating erythroid progenitors in the peripheral blood, this did not reach statistical significance compared to controls as seen in other studies. 46 , 51 However, other studies of less severe injury only identified mobilization of erythroid progenitors with the addition of restraint stress to simulate the intensive care unit. 27 , 47 Therefore, perhaps this additional restraint stress may impact the mobilization of erythroid progenitors to the peripheral blood in addition to injury on day seven.

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