Chronic inflammation with microglia senescence at basal forebrain: impact on cholinergic deficit in Alzheimer's brain haemodynamics.

In contrast, in old 3xTgAD mice, the mean % ΔrCBF to ACh tended to be lower than in age-matched old WT mice, although it did not reach statistical significance ( Fig. 2C ), but it was significantly lower than the that in middle-aged 3xTgAD mice ( Fig. 2E , * P ≤ 0.05, n = 5–6 mice/group).

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