Spatial transcriptomics analysis identifies a tumor-promoting function of the meningeal stroma in melanoma leptomeningeal disease.

Three LMD tissues had a sufficient number of stromal cells to examine the changes in the tumor SERPINA3 expression at increasing distance intervals from the stroma, and all three tissues showed a trend of expression decreasing at intervals further away from the stroma ( p < 0.001, p = 1, and p < 0.001 for samples 7, 2, and 8, respectively, Figure S5 B).

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