Ribosomal DNA copy number variation associates with hematological profiles and renal function in the UK Biobank.

31 Indeed, Cystatin C remained the most strongly associated with rDNA CN in a multivariate linear model including all blood biochemistry biomarkers related to renal function simultaneously, regardless of whether they appeared as nominally significant on their own ( Figure S16 A; this occurs both with and without C-Reactive Protein, a well-established marker of inflammation, as a covariate).

also in 7,732 other papers

rDNA CN shows strong familial correlations, but is not associated with genetic variation elsewhere in the genome Pairwise comparisons in monozygotic (MZ) twins, first-, second-, and third-degree relatives with both individuals sequenced in the same sequencing center batch showed highly significant correlations, and an expected decrease in Pearson’s R with distance, from 0.95 to 0.11 ( Figure 1 F; using sequencing center-adjusted estimates on all pairs yields similar results; Figure S7 ).

also in 132,142 other papers