Non-motor symptoms in patients with amyotrophic lateral sclerosis: current state and future directions.

Cramps typically emerged early in the disease, with a decreasing trend observed in subsequent years (mean number of cramps in the first year was 46.3 ± 95.7, in the second year was 37.6 ± 62.5, and in the third year was 24.1 ± 31.7).

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However, it is worth noting that this trend did not reach statistical significance.

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