Clinical effectiveness of pit and fissure sealants in primary and permanent teeth of children and adolescents: an umbrella review.

For all these follow-ups, meta-analyses showed highly significant results for the comparison between resin-based sealants and not treatment ( p < 0.00001) meaning that resin-based sealants efficiently prevented caries in children’s first permanent molars.

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2009 ) comparing pit and fissure sealings with HVGIC applied by press-finger technique versus the conventional application of resin-based sealants and found no significant differences for both for follow-ups up to 48 months “[...] and borderline significant differences in favour of HVGIC sealants after 60 months (RR 0.29; 95% CI: 0.09–0.95; p = 0.04/RD -0.07; 95% CI: -0.14, -0.01) [...]” (Mickenautsch and Yengopal 2016 ).

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For the 4741 included participants, the caries risk reduction of 29% for GI-based versus resin-based sealings did not reach statistical significance ( p = 0.39).

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