Osteoblast-specific down-regulation of NLRP3 inflammasome by aptamer-functionalized liposome nanoparticles improves bone quality in postmenopausal osteoporosis rats.

Fluorescence signal intensity of CH6-LNPs-siNLRP3 in bone was significantly higher, whereas the fluorescence signal intensities in liver and kidney were lower compared to that of LNPs-siNLRP3 at 4 h after a tail vein injection, the differences did not reach statistical significance in the kidney (Figure 4 A, C-E).

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